Glucosamine might enhance the effects of tetracycline, a common antibiotic, and decrease the effects of penicillin and chloramphenicol. Glucosamine sulfate may interact with potassium chloride, a medication used to treat high blood pressure. Please take this into account when using blood pressure regulating medication. As always, please seek advice from a health care professional before starting the use of glucosamine, especially if you are currently taking any medication.